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2016-02-09 - Article/Dans un journal avec peer-review - Anglais - 11 page(s) (Soumise)

Pardo Antonelle, Josse Thomas, Mespouille Laetitia , Dubois Philippe , Blankert Bertrand , Duez Pierre , "Grafting of oligoethylene glycol units on molecularly imprinted polymers: A method to improve the capture of template analogues" in Phytochemical Analysis, Soumis pour publication

  • Edition : John Wiley & Sons Ltd., West Sussex (United Kingdom)
  • Codes CREF : Chimie des polymères de synthèse (DI131C), Chimie analytique (DI1314), Pharmacognosie (DI3410), Sciences pharmaceutiques (DI3400)
  • Unités de recherche UMONS : Matériaux Polymères et Composites (S816), Analyse pharmaceutique (M130), Chimie thérapeutique et Pharmacognosie (M136)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Centre d’Innovation et de Recherche en Matériaux Polymères (CIRMAP)

Abstract(s) :

(Anglais) A new synthesis strategy of molecularly imprinted polymers (MIPs) is presented herein in order to mimic the flexibility and mobility exhibited by receptor/enzyme binding pockets. An additional comonomer bearing a small oligoethylene glycol (OEG) side chain was used to prepare a quercetin imprinted polymer (Qu MIP) which was compared to a traditional Qu MIP formulated in a similar fashion, without introduction of OEG-comonomer. The Qu MIPs were prepared in bead form through fluorocarbon suspension polymerization in the presence of a perfluorinated surfactant. After SPE assessment of the presence of imprinted cavities, the selectivity of MIPs was evaluated by HPLC according to their recognition to quercetin, other flavonoids, phenolic acids and an unrelated compound (curcumin). The obtained results demonstrated the modulation of selectivity thanks to the presence of OEG units which were also able to limit or suppress non-specific hydrophobic interactions. The Qu MIPs offered therefore promising perspectives to selectively extract analytes of interest amongst interferent compounds in complex systems. Indeed, the SPE application of MIPs to a white onion extract appeared extremely interesting on one hand, for the selective extraction of quercetin and on the other hand, for the concomitant discovery of new drug candidates, promising sources of therapeutic benefits.