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2017-07-06 - Article/Dans un journal avec peer-review - Anglais - 11 page(s)

Duquesne Marilyn, Decleves Anne-Emilie , Deprez Eric, Nortier Joëlle, Colet Jean-Marie , "Interest of metabonomic approach in environmental nephrotoxicants : Application to aristolochic acid epxosure" in Food & Chemical Toxicology

  • Edition : Elsevier Science, Exeter (United Kingdom)
  • Codes CREF : Biologie (DI3100), Sciences exactes et naturelles (DI1000), Toxicologie [toxines] (DI3236)
  • Unités de recherche UMONS : Biologie moléculaire (M122), Biologie humaine et Toxicologie (M125)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Centre de Recherche UMONS-Ambroise Paré (UMHAP)
Texte intégral :

Abstract(s) :

(Anglais) Aristolochic acid (AA) is a powerful nephrotoxicant consisted of a mixture of Aristolochic acid I and 21 II. It is produced by some plants from the Aristolochiaceae family widely used in traditional medicines. 22 Due to severe adverse effects, including urothelial cancers and renal failure, encountered in self- 23 medicating patients, Aristolochia-based remedies are nowadays forbidden in Europe, United States, and 24 Australia. Nevertheless, those plants are still commonly used as herbal remedies in other parts of the 25 world. Moreover, Aristolochia food contamination is currently considered as the main environmental 26 factor causing a nephropathy widespread in several rural area of Balkan countries. Our laboratory has 27 developed Wistar Han rat models representative of acute and chronic AA-induced nephrotoxicity. 28 Therefore, we studied the urinary metabonomic profiles of these rats in order to examine the respective 29 toxicity of these compounds. This new "omic" concept allowed to identify which part of the kidney is 30 mostly affected, the toxic mode of action and to find out potential early urinary biomarkers of the renal 31 disease. Here, the metabonomic results were associated with morphological analysis of the kidney tissue 32 to assess the tubular and interstitial structures consecutive to AA exposure.